On the day before a critical med school interview, straight A college student Jeff Chang gets a surprise visit from his two best buds to celebrate his twenty-first birthday. In no mood to party, Jeff finally agrees to a single drink, which quickly leads to an over-the-top, out-of-control night filled with epic beer pong, smoking hot coeds and one angry buffalo. Can Jeff's friends get their plastered pal cleaned up in time for his morning appointment?