Welcome to 1876 America, a place bursting with gunslingers, outlaws, and garou, better known as werewolves. After a garou hunt goes south and Calamity Jane finds a suspicious bite on her arm, she turns tail for Deadwood, where there's talk of a garou cure. But rumors can be deceiving, meaning the gang better hightail it after her before they're a day late and a Jane short.